PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans.

doi:10.1038/s41591-021-01572-7

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans.

Nature medicine - 1 Dec 2021

Barak Tanyeri, Ristori Emma, Ercan-Sencicek A Gulhan, Miyagishima Danielle F, Nelson-Williams Carol, Dong Weilai, Jin Sheng Chih, Prendergast Andrew, Armero William, Henegariu Octavian, Erson-Omay E Zeynep, Harmancı Akdes Serin, Guy Mikhael, Gültekin Batur, Kilic Deniz, Rai Devendra K, Goc Nükte, Aguilera Stephanie Marie, Gülez Burcu, Altinok Selin, Ozcan Kent, Yarman Yanki, Coskun Süleyman, Sempou Emily, Deniz Engin, Hintzen Jared, Cox Andrew, Fomchenko Elena, Jung Su Woong, Ozturk Ali Kemal, Louvi Angeliki, Bilgüvar Kaya, Connolly E Sander, Khokha Mustafa K, Kahle Kristopher T, Yasuno Katsuhito, Lifton Richard P, Mishra-Gorur Ketu, Nicoli Stefania, Günel Murat

Abstract excerpt

Intracranial aneurysm (IA) rupture leads to subarachnoid hemorrhage, a sudden-onset disease that often causes death or severe disability. Although genome-wide association studies have identified common genetic variants that increase IA risk moderately, the contribution of variants with large effect remains poorly defined. Using whole-exome sequencing, we identified significant enrichment of rare, deleterious...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain

Share to Cyclophilins

Share to Exome Sequencing

Share to Intracranial Aneurysm

Share to Mutation

Share to Neovascularization, Pathologic

Share to RNA-Binding Proteins

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 34887573
DOI: 10.1038/s41591-021-01572-7
PMCID: PMC8768030

Genes

PPIL4
JMJD6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans.PMID 34887573Read ↗

Multi-ancestry proteogenomic analysis identifies risk proteins for intracranial aneurysmsSemantic proximity Read ↗

Intracranial Aneurysms and Genetics: An Extensive Overview of Genomic Variations, Underlying Molecular Dynamics, Inflammatory Indicators, and Forward-Looking InsightsSemantic proximity Read ↗

Angiopoietin-like 4 (ANGPTL4) gene polymorphisms and risk of brain arteriovenous malformations.Semantic proximity Read ↗

Understanding the pathogenesis of brain arteriovenous malformation: genetic variations, epigenetics, signaling pathways, and immune inflammation.Semantic proximity Read ↗

ANGPTL6 variant induces cerebral vascular dysfunction and predisposes to intracranial aneurysm in miceSemantic proximity Read ↗

Identifying novel risk genes in intracranial aneurysm by integrating human proteomes and genetics.Semantic proximity Read ↗

Genome-wide linkage analysis combined with genome sequencing in large families with intracranial aneurysms.Semantic proximity Read ↗

Perturbations of BMP/TGF-β and VEGF/VEGFR signalling pathways in non-syndromic sporadic brain arteriovenous malformations (BAVM).Semantic proximity Read ↗

Neuroinflammation plays a critical role in cerebral cavernous malformation diseaseSemantic proximity Read ↗

Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors.Semantic proximity Read ↗

Integrative bioinformatics analysis of miRNA and mRNA expression profiles and identification of associated miRNA-mRNA network in intracranial aneurysmsSemantic proximity Read ↗

PRCP is a promising drug target for intracranial aneurysm rupture supported via multi-omics analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.