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Article

The proteome, not the transcriptome, predicts that oocyte superovulation affects embryonic phenotypes in mice.

Scientific reports - 9 Dec 2021

Taher Leila, Israel Steffen, Drexler Hannes C A, Makalowski Wojciech, Suzuki Yutaka, Fuellen Georg, Boiani Michele

Abstract excerpt

Superovulation is the epitome for generating oocytes for molecular embryology in mice, and it is used to model medically assisted reproduction in humans. However, whether a superovulated oocyte is normal, is an open question. This study establishes for the first time that superovulation is associated with proteome changes that affect phenotypic traits in mice, whereas the transcriptome is far less predictive. The...

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Identifiers

PMID: 34887460
DOI: 10.1038/s41598-021-03054-9
PMCID: PMC8660899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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