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Single-cell proteomics analysis of human oocytes during GV-to-MI transition

13 May 2025

Abstract excerpt

STUDY QUESTION: Which proteins are involved in the transition of human oocytes from the germinal vesicle (GV) to metaphase I (MI) phase? SUMMARY ANSWER: A total of 2369 proteins were identified, including 149 with significantly differential expression, 79 with upregulated expression in MI oocytes and 70 with downregulated expression. WHAT IS KNOWN ALREADY: During oocyte maturation, maternal proteins and RNA are...

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PMID: 40359387
DOI: 10.1093/humrep/deaf086

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