Article

The Proteome, Not the Transcriptome, Predicts that Oocyte Superovulation Affects Embryonic Phenotypes in Mice

2021-07-28

Abstract excerpt

Superovulation is the epitome for generating oocytes for molecular embryology in mice, and it is used to model medically assisted reproduction in humans. Yet whether a superovulated oocyte is normal, is an open question. This study establishes for the first time that superovulation is associated with proteome changes that bear on phenotypic traits in mice, whereas the transcriptome is far less predictive. The prot...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1f7c2ba8-42dc-53f8-8818-fc6cd543b6b0
DOI: 10.21203/rs.3.rs-724812/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Proteome, Not the Transcriptome, Predicts that Oocyte Superovulation Affects Embryonic Phenotypes in MiceDOI 10.21203/rs.3.rs-724812/v1Read

The proteome, not the transcriptome, predicts that oocyte superovulation affects embryonic phenotypes in mice.Semantic proximity Read

Single-Cell Quantitative Proteomic Analysis of Human Oocyte Maturation Revealed High Heterogeneity in In Vitro–Matured OocytesSemantic proximity Read

A proteomic signature of oocyte quality from models of varying oocyte developmental competenceSemantic proximity Read

Granulosa cell transcription is similarly impacted by superovulation and aging and predicts early embryonic trajectoriesSemantic proximity Read

Proteomic-based identification of maternal proteins in mature mouse oocytesSemantic proximity Read

Oocyte quality and maternal control of development.Semantic proximity Read

Superovulation and aging perturb oocyte-granulosa cell communicationSemantic proximity Read

Developmental competence in oocytes and cumulus cells: candidate genes and networksSemantic proximity Read

Single-cell proteomics analysis of human oocytes during GV-to-MI transitionSemantic proximity Read

Transcriptomic profiles reveal the characteristics of oocytes and cumulus cells at GV, MI, and MII in follicles before ovulationSemantic proximity Read

Proteome of mouse oocytes at different developmental stagesSemantic proximity Read

Single-cell DNA methylation sequencing reveals epigenetic alterations in mouse oocytes superovulated with different dosages of gonadotropinsSemantic proximity Read