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Article

Origin and evolution of the RIG-I like RNA helicase gene family

1 Jan 2009

Abstract excerpt

BACKGROUND: The DExD/H domain containing RNA helicases such as retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) are key cytosolic pattern recognition receptors (PRRs) for detecting nucleotide pathogen associated molecular patterns (PAMPs) of invading viruses. The RIG-I and MDA5 proteins differentially recognise conserved PAMPs in double stranded or single stranded viral...

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PMID: 19400936
DOI: 10.1186/1471-2148-9-85

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