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Article

RNA interference directs innate immunity against viruses in adult Drosophila.

Science (New York, N.Y.) - 21 Apr 2006

Wang Xiao-Hong, Aliyari Roghiyh, Li Wan-Xiang, Li Hong-Wei, Kim Kevin, Carthew Richard, Atkinson Peter, Ding Shou-Wei

Abstract excerpt

Innate immunity against bacterial and fungal pathogens is mediated by Toll and immune deficiency (Imd) pathways, but little is known about the antiviral response in Drosophila. Here, we demonstrate that an RNA interference pathway protects adult flies from infection by two evolutionarily diverse viruses. Our work also describes a molecular framework for the viral immunity, in which viral double-stranded RNA...

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Identifiers

PMID: 16556799
DOI: 10.1126/science.1125694
PMCID: PMC1509097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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