Article
Promoter-Driven Overexpression in Chromobacterium vaccinii Facilitates Access to FR900359 and Yields Novel Low Abundance Analogs.
Chemistry (Weinheim an der Bergstrasse, Germany) - 7 Feb 2022
Pistorius Dominik, Buntin Kathrin, Weber Eric, Richard Etienne, Bouquet Caroline, Wollbrett Séverine, Regenass Hugo, Peón Victor, Böhm Marcel, Kessler Régis, Gempeler Thomas, Haberkorn Anne, Wimmer Laurin, Lanshoeft Christian, Davis John, Hainzl Dominik, D'Alessio Joseph Anthony, Manchado Eusebio, Petersen Frank
Abstract excerpt
Access to the cyclic depsipeptide FR900359 (FR), a selective Gq/11 protein inhibitor of high pharmacological interest and a potential lead molecule for targeted therapy of cancers with oncogenic GNAQ or GNA11 mutations (encoding Gq and G11 respectively), has been challenging ever since its initial discovery more than three decades ago. The recent discovery of Chromobacterium vaccinii as a cultivable FR producer...
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