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Article

Genomic landscapes by multiregion sequencing combined with circulation tumor DNA detection contribute to molecular diagnosis in glioblastomas.

Aging - 10 Dec 2019

Yang Chao, Tan Yanli, Li Shouwei, Zhou Junhu, Wang Qixue, Wang Yunfei, Xie Yingbin, Chen Luyue, Li Jie, Fang Chuan, Kang Chunsheng

Abstract excerpt

Glioblastoma is a highly aggressive brain malignancy with a poor prognosis. Its high intratumor heterogeneity contributes to therapeutic resistance, tumor progression and recurrence. We sequenced 31 loci in 11 patients with glioblastoma (including one patient with samples available from the primary and recurrent tumors) to determine the genetic basis and intratumor heterogeneity of glioblastoma. By analyzing the...

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Identifiers

PMID: 31822636
DOI: 10.18632/aging.102526
PMCID: PMC6932900

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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