Angiotensin-(1-7)/MasR axis promotes migration of monocytes/macrophages with a regulatory phenotype to perform phagocytosis and efferocytosis.

doi:10.1172/jci.insight.147819

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Article

Angiotensin-(1-7)/MasR axis promotes migration of monocytes/macrophages with a regulatory phenotype to perform phagocytosis and efferocytosis.

JCI insight - 11 Jan 2022

Zaidan Isabella, Tavares Luciana P, Sugimoto Michelle A, Lima Kátia M, Negreiros-Lima Graziele L, Teixeira Lívia Cr, Miranda Thais C, Valiate Bruno Vs, Cramer Allysson, Vago Juliana Priscila, Campolina-Silva Gabriel H, Souza Jéssica Am, Grossi Laís C, Pinho Vanessa, Campagnole-Santos Maria Jose, Santos Robson As, Teixeira Mauro M, Galvão Izabela, Sousa Lirlândia P

Abstract excerpt

Nonphlogistic migration of macrophages contributes to the clearance of pathogens and apoptotic cells, a critical step for the resolution of inflammation and return to homeostasis. Angiotensin-(1-7) [Ang-(1-7)] is a heptapeptide of the renin-angiotensin system that acts through Mas receptor (MasR). Ang-(1-7) has recently emerged as a novel proresolving mediator, yet Ang-(1-7) resolution mechanisms are not fully...

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Identifiers

PMID: 34874920
DOI: 10.1172/jci.insight.147819
PMCID: PMC8765051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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