Article
HLA-H*02:07 Is a Membrane-Bound Ligand of Denisovan Origin That Protects against Lysis by Activated Immune Effectors.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2022
Hubert Lucas, Paganini Julien, Picard Christophe, Chiaroni Jacques, Abi-Rached Laurent, Pontarotti Pierre, Di Cristofaro Julie
Abstract excerpt
The biological relevance of genes initially categorized as "pseudogenes" is slowly emerging, notably in innate immunity. In the HLA region on chromosome 6, HLA-H is one such pseudogene; yet, it is transcribed, and its variation is associated with immune properties. Furthermore, two HLA-H alleles, H*02:07 and H*02:14, putatively encode a complete, membrane-bound HLA protein. Here we thus hypothesized that HLA-H...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.