Article
HLA-J, a second inactivated class I HLA gene related to HLA-G and HLA-A. Implications for the evolution of the HLA-A-related genes.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1992
Messer G, Zemmour J, Orr H T, Parham P, Weiss E H, Girdlestone J
Abstract excerpt
Ragoussis and co-workers (Genomics 4:301) previously described a class I HLA gene (now designated HLA-J) that maps to within 50 kb of HLA-A. The nucleotide sequences of three HLA-J alleles are reported here. Comparison of the nucleotide sequences of HLA-J alleles shows this gene is more related to HLA-G, A, and H than to HLA-B, C, E, and F. All four alleles of HLA-J are pseudogenes because of deleterious...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Biological Evolution
- Chromosome Deletion
- Consensus Sequence
- Enhancer Elements, Genetic
- Exons
- Genes, MHC Class I
- Histocompatibility Antigens Class I