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Measuring Mutator Enzyme Activity Using an E. coli-Based Colony Formation Assay.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2022

Liu Mei-Chen, Fugmann Sebastian D

Abstract excerpt

Mutator enzymes alter the nucleotide sequences of DNA or RNA molecules; immune systems utilize them to destroy the integrity of pathogen genomes and to optimize immune mediators of the host. Their dysregulation has been linked to tumorigenesis in various tissues. Defining and comparing the activities of such mutator enzymes requires a robust versatile assay that is independent of their biological context as in...

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PMID: 34870814
DOI: 10.1007/978-1-0716-1944-5_7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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