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Article

Blocking STAT3 by pyrvinium pamoate causes metabolic lethality in KRAS-mutant lung cancer.

Biochemical pharmacology - 1 Jul 2020

Feng JuanJuan, Jiang Wenhao, Liu Yanan, Huang Wanfeng, Hu Kewen, Li Kun, Chen Jing, Ma Chengbin, Sun Zhenliang, Pang Xiufeng

Abstract excerpt

Signal transducer and activator of transcription 3 (STAT3) exerts a profound role in regulating mitochondrial function and cellular metabolism. Mitochondrial STAT3 supports RAS-dependent malignant transformation and tumor growth. However, whether pharmacological blockade of STAT3 leads to metabolic lethality in KRAS-mutant lung cancer remains unclear. Pyrvinium pamoate, a clinical antihelminthic drug,...

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Identifiers

PMID: 32298693
DOI: 10.1016/j.bcp.2020.113960

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