Article
Genomics and transcriptomics landscapes associated to changes in insulin sensitivity in response to endurance exercise training.
Scientific reports - 2 Dec 2021
Takeshita Louise Y, Davidsen Peter K, Herbert John M, Antczak Philipp, Hesselink Matthijs K C, Schrauwen Patrick, Weisnagel S John, Robbins Jeremy M, Gerszten Robert E, Ghosh Sujoy, Sarzynski Mark A, Bouchard Claude, Falciani Francesco
Abstract excerpt
Despite good adherence to supervised endurance exercise training (EET), some individuals experience no or little improvement in peripheral insulin sensitivity. The genetic and molecular mechanisms underlying this phenomenon are currently not understood. By investigating genome-wide variants associated with baseline and exercise-induced changes (∆) in insulin sensitivity index (Si) in healthy volunteers, we have...
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