Article
Intermittent fasting and caloric restriction interact with genetics to shape physiological health in mice.
Genetics - 4 Jan 2022
Zhang Guozhu, Deighan Andrew, Raj Anil, Robinson Laura, Donato Hannah J, Garland Gaven, Leland Mackenzie, Martin-McNulty Baby, Kolumam Ganesh A, Riegler Johannes, Freund Adam, Wright Kevin M, Churchill Gary A
Abstract excerpt
Dietary interventions can dramatically affect physiological health and organismal lifespan. The degree to which organismal health is improved depends upon genotype and the severity of dietary intervention, but neither the effects of these factors, nor their interaction, have been quantified in an outbred population. Moreover, it is not well understood what physiological changes occur shortly after dietary change...
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