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TERT genetic variability and telomere length as factors affecting survival and risk in acute myeloid leukaemia

2 Dec 2021

Abstract excerpt

Acute myeloid leukaemia (AML) is a neoplasm of immature myeloid cells characterized by various cytogenetic alterations. The present study showed that in addition to the FLT3-ITD and NPM1 mutation status, telomere length (TL) and telomerase reverse transcriptase (TERT) gene polymorphisms may affect risk and overall survival (OS) in AML. TL was longer in healthy controls than in AML patients and positively...

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Share to Acute Myeloid Leukemia Research
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PMID: 34857839
DOI: 10.1038/s41598-021-02767-1

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