Article
Telomere length and genetic variation in telomere maintenance genes in relation to ovarian cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 2012
Terry Kathryn L, Tworoger Shelley S, Vitonis Allison F, Wong Jason, Titus-Ernstoff Linda, De Vivo Immaculata, Cramer Daniel W
Abstract excerpt
BACKGROUND: Telomeres protect chromosomal ends, shorten with cellular division, and signal cellular senescence, but unchecked telomere attrition can lead to telomere dysfunction, upregulation of telomerase, and carcinogenesis. Shorter telomeres in peripheral blood leukocytes (PBL) have been associated with elevated cancer risk. Furthermore, genetic variants in and around the TERT gene have been implicated in...
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