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Article

Potential role of the ABCG2-Q141K polymorphism in type 2 diabetes.

PloS one - 1 Jan 2021

Szabó Edit, Kulin Anna, Mózner Orsolya, Korányi László, Literáti-Nagy Botond, Vitai Márta, Cserepes Judit, Sarkadi Balázs, Várady György

Abstract excerpt

Type 2 diabetes mellitus (T2DM) is a complex metabolic disease and variations in multispecific membrane transporter functions may affect T2DM development, complications or treatment. In this work we have analyzed the potential effects of a major polymorphism, the Q141K variant of the ABCG2 transporter in T2DM. The ABCG2 protein is a multispecific xeno- and endobiotic transporter, affecting drug metabolism and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34855903
DOI: 10.1371/journal.pone.0260957
PMCID: PMC8638943

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