Article
Association of functional polymorphism rs2231142 (Q141K) in the ABCG2 gene with serum uric acid and gout in 4 US populations: the PAGE Study.
American journal of epidemiology - 1 May 2013
Zhang Lili, Spencer Kylee L, Voruganti V Saroja, Jorgensen Neal W, Fornage Myriam, Best Lyle G, Brown-Gentry Kristin D, Cole Shelley A, Crawford Dana C, Deelman Ewa, Franceschini Nora, Gaffo Angelo L, Glenn Kimberly R, Heiss Gerardo, Jenny Nancy S, Kottgen Anna, Li Qiong, Liu Kiang, Matise Tara C, North Kari E, Umans Jason G, Kao W H Linda
Abstract excerpt
A loss-of-function mutation (Q141K, rs2231142) in the ATP-binding cassette, subfamily G, member 2 gene (ABCG2) has been shown to be associated with serum uric acid levels and gout in Asians, Europeans, and European and African Americans; however, less is known about these associations in other populations. Rs2231142 was genotyped in 22,734 European Americans, 9,720 African Americans, 3,849 Mexican Americans, and...
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