CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment.

doi:10.1016/j.celrep.2021.110060

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Article

CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment.

Cell reports - 30 Nov 2021

Klomp Jennifer E, Lee Ye S, Goodwin Craig M, Papke Björn, Klomp Jeff A, Waters Andrew M, Stalnecker Clint A, DeLiberty Jonathan M, Drizyte-Miller Kristina, Yang Runying, Diehl J Nathaniel, Yin Hongwei H, Pierobon Mariaelena, Baldelli Elisa, Ryan Meagan B, Li Siqi, Peterson Jackson, Smith Amber R, Neal James T, McCormick Aaron K, Kuo Calvin J, Counter Christopher M, Petricoin Emanuel F, Cox Adrienne D, Bryant Kirsten L, Der Channing J

Abstract excerpt

We apply genetic screens to delineate modulators of KRAS mutant pancreatic ductal adenocarcinoma (PDAC) sensitivity to ERK inhibitor treatment, and we identify components of the ATR-CHK1 DNA damage repair (DDR) pathway. Pharmacologic inhibition of CHK1 alone causes apoptotic growth suppression of both PDAC cell lines and organoids, which correlates with loss of MYC expression. CHK1 inhibition also activates ERK...

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Identifiers

PMID: 34852220
DOI: 10.1016/j.celrep.2021.110060
PMCID: PMC8665414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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