Article
The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer.
The Journal of biological chemistry - 1 Nov 2021
Diehl J Nathaniel, Klomp Jennifer E, Snare Kayla R, Hibshman Priya S, Blake Devon R, Kaiser Zane D, Gilbert Thomas S K, Baldelli Elisa, Pierobon Mariaelena, Papke Björn, Yang Runying, Hodge Richard G, Rashid Naim U, Petricoin Emanuel F, Herring Laura E, Graves Lee M, Cox Adrienne D, Der Channing J
Abstract excerpt
Oncogenic KRAS drives cancer growth by activating diverse signaling networks, not all of which have been fully delineated. We set out to establish a system-wide profile of the KRAS-regulated kinase signaling network (kinome) in KRAS-mutant pancreatic ductal adenocarcinoma (PDAC). We knocked down KRAS expression in a panel of six cell lines and then applied multiplexed inhibitor bead/MS to monitor changes in...
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