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Article

TORC1 signaling modulates Cdk8-dependent GAL gene expression in Saccharomyces cerevisiae.

Genetics - 10 Dec 2021

Horvath Riley, Hawe Nicole, Lam Cindy, Mestnikov Konstantin, Eji-Lasisi Mariam, Rohde John, Sadowski Ivan

Abstract excerpt

Cdk8 of the RNA polymerase II mediator kinase complex regulates gene expression by phosphorylating sequence-specific transcription factors. This function is conserved amongst eukaryotes, but the signals and mechanisms regulating Cdk8 activity and phosphorylation of its substrates are unknown. Full induction of the GAL genes in yeast requires phosphorylation of the transcriptional activator Gal4 by Cdk8. We used a...

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Identifiers

PMID: 34849833
DOI: 10.1093/genetics/iyab168
PMCID: PMC8664586

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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