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Article

Multiple signals regulate GAL transcription in yeast.

Molecular and cellular biology - 1 Jun 2000

Rohde J R, Trinh J, Sadowski I

Abstract excerpt

Gal4p activates transcription of the Saccharomyces GAL genes in response to galactose and is phosphorylated during interaction with the RNA polymerase II (Pol II) holoenzyme. One phosphorylation at S699 is necessary for full GAL induction and is mediated by Srb10p/CDK8 of the RNA Pol II holoenzyme mediator subcomplex. Gal4p S699 phosphorylation is necessary for sensitive response to inducer, and its requirement...

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Source

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Identifiers

PMID: 10805731
DOI: 10.1128/MCB.20.11.3880-3886.2000
PMCID: PMC85726

Genes

GAL
CDK8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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