Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Emerging Therapeutic Implications of STK11 Mutation: Case Series.

The oncologist - 1 Sept 2020

Laderian Bahar, Mundi Prabhjot, Fojo Tito, E Bates Susan

Abstract excerpt

STK11 was first recognized as a tumor suppressor gene in the late 1990s based on linkage analysis of patients with Peutz-Jeghers syndrome. STK11 encodes LKB1, an intracellular serine-threonine kinase involved in cellular metabolism, cell polarization, regulation of apoptosis, and DNA damage response. Recurrent somatic loss-of-function mutations occur in multiple cancer types, most notably in 13% of lung...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma of Lung
Share to AMP-Activated Protein Kinase Kinases
Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ-Line Mutation

Share to Lung Neoplasms

Share to Peutz-Jeghers Syndrome

Share to Protein Serine-Threonine Kinases

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 32396674
DOI: 10.1634/theoncologist.2019-0846
PMCID: PMC7485370

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Emerging Therapeutic Implications of STK11 Mutation: Case Series.PMID 32396674Read ↗

Gene of the month: STK11.Semantic proximity Read ↗

STK11 (LKB1) mutations in metastatic NSCLC: Prognostic value in the real world.Semantic proximity Read ↗

STK11 alterations in the pan-cancer setting: prognostic and therapeutic implications.Semantic proximity Read ↗

Prevalence and clinico-morphological correlates of STK11 mutations in a large cohort of NSCLC lung adenocarcinomas.Semantic proximity Read ↗

Loss of STK11 Suppresses Lipid Metabolism and Attenuates KRAS-Induced Immunogenicity in Patients with Non-Small Cell Lung Cancer.Semantic proximity Read ↗

STK11/LKB1 Modulation of the Immune Response in Lung Cancer: From Biology to Therapeutic Impact.Semantic proximity Read ↗

STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma.Semantic proximity Read ↗

A Sensitive NanoString-Based Assay to Score STK11 (LKB1) Pathway Disruption in Lung Adenocarcinoma.Semantic proximity Read ↗

A Critical Review of the Prognostic and Predictive Implications of KRAS and STK11 Mutations and Co-Mutations in Metastatic Non-Small Lung CancerSemantic proximity Read ↗

LKB1/STK11 mutations in non-small cell lung cancer patients: Descriptive analysis and prognostic value.Semantic proximity Read ↗

Lung cancer as a predominant feature in a patient with Peutz-Jeghers syndrome: Case report.Semantic proximity Read ↗

Clinical impact of STK11 mutation in advanced-stage non-small cell lung cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.