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Transcriptional Factor Repertoire of Breast Cancer in 3D Cell Culture Models

17 Feb 2022

Abstract excerpt

Intratumor heterogeneity of breast cancer is driven by extrinsic factors from the tumor microenvironment (TME) as well as tumor cell-intrinsic parameters including genetic, epigenetic, and transcriptomic traits. The extracellular matrix (ECM), a major structural component of the TME, impacts every stage of tumorigenesis by providing necessary biochemical and biomechanical cues that are major regulators of cell...

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PMID: 35205770
DOI: 10.3390/cancers14041023

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