Power calculator for detecting allelic imbalance using hierarchical Bayesian model.

doi:10.1186/s13104-021-05851-x

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Article

Power calculator for detecting allelic imbalance using hierarchical Bayesian model.

BMC research notes - 27 Nov 2021

Sherbina Katrina, León-Novelo Luis G, Nuzhdin Sergey V, McIntyre Lauren M, Marroni Fabio

Abstract excerpt

OBJECTIVE: Allelic imbalance (AI) is the differential expression of the two alleles in a diploid. AI can vary between tissues, treatments, and environments. Methods for testing AI exist, but methods are needed to estimate type I error and power for detecting AI and difference of AI between conditions. As the costs of the technology plummet, what is more important: reads or replicates? RESULTS: We find that a...

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PMID: 34838135
DOI: 10.1186/s13104-021-05851-x
PMCID: PMC8626927

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