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Article

Prevention and partial reversion of the lupus phenotype in ABIN1[D485N] mice by an IRAK4 inhibitor.

Lupus science & medicine - 1 Nov 2021

Petrova Tsvetana, Nanda Sambit K, Scudamore Cheryl, Wright Stephen W, Rao Vikram R, Cohen Philip

Abstract excerpt

OBJECTIVE: We have reported previously that the IRAK4 inhibitor PF06426779 given to ubiquitin-binding-defective ABIN1[D485N] mice at 6 weeks of age prevents the major facets of lupus that develop 10 weeks later. The present study was undertaken to investigate whether PF06426779 could reverse the lupus phenotype when administered to 13-week-old ABIN1[D485N] mice that had already developed symptoms of lupus....

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Identifiers

PMID: 34836923
DOI: 10.1136/lupus-2021-000573
PMCID: PMC8628323

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