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Article

Polyubiquitin binding to ABIN1 is required to prevent autoimmunity.

The Journal of experimental medicine - 6 Jun 2011

Nanda Sambit K, Venigalla Ram K C, Ordureau Alban, Patterson-Kane Janet C, Powell David W, Toth Rachel, Arthur J Simon C, Cohen Philip

Abstract excerpt

The protein ABIN1 possesses a polyubiquitin-binding domain homologous to that present in nuclear factor κB (NF-κB) essential modulator (NEMO), a component of the inhibitor of NF-κB (IκB) kinase (IKK) complex. To address the physiological significance of polyubiquitin binding, we generated knockin mice expressing the ABIN1[D485N] mutant instead of the wild-type (WT) protein. These mice developed all the hallmarks...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21606507
DOI: 10.1084/jem.20102177
PMCID: PMC3173241

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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