Article

A maternal high-fat diet predisposes to infant lung disease via increased neutrophil-mediated IL-6 trans-signaling

2024-03-15

Abstract excerpt

Poor maternal diet during pregnancy predisposes to severe lower respiratory tract infections (sLRI) in infancy, which in turn, increases childhood asthma risk, however the underlying mechanisms remain poorly understood. Here, we show that the offspring of high fat diet (HFD)-fed mothers (‘HFD-reared pups’) developed a sLRI following pneumovirus inoculation in early-life and subsequent asthma in later-life upon all...

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Literature Corpus work: ddaea8a7-5c14-5230-ac5b-db9c5b0145b9
DOI: 10.1101/2024.03.13.584927

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