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Article

Impact of HIV-1 Envelope Conformation on ADCC Responses

20 Nov 2017

Abstract excerpt

HIV-1 envelope glycoproteins (Env) represent the only virus-specific antigen exposed at the surface of infected cells. In its unliganded form, Env from primary viruses samples a 'closed' conformation (State 1), which is preferentially recognized by broadly neutralizing antibodies (bNAbs). CD4 engagement drives Env into an intermediate 'partially open' (State 2) and then into the 'open' CD4-bound conformation...

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PMID: 29162391
DOI: 10.1016/j.tim.2017.10.007

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