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Article

Calvaria Bone Transcriptome in Mouse Models of Osteogenesis Imperfecta.

International journal of molecular sciences - 18 May 2021

Moffatt Pierre, Boraschi-Diaz Iris, Marulanda Juliana, Bardai Ghalib, Rauch Frank

Abstract excerpt

Osteogenesis imperfecta (OI) is a bone fragility disorder that is usually caused by mutations affecting collagen type I. We compared the calvaria bone tissue transcriptome of male 10-week-old heterozygous Jrt (Col1a1 mutation) and homozygous oim mice (Col1a2 mutation) to their respective littermate results. We found that Jrt and oim mice shared 185 differentially expressed genes (upregulated: 106 genes;...

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Identifiers

PMID: 34069814
DOI: 10.3390/ijms22105290
PMCID: PMC8157281

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