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Article

Deregulated NLRP3 and NLRP1 Inflammasomes and Their Correlations with Disease Activity in Systemic Lupus Erythematosus

15 Dec 2013

Abstract excerpt

OBJECTIVE: NOD-like receptor family, pyrin domain containing 3 and 1 (NLRP3 and NLRP1) inflammasomes are molecular platforms that sense the damage or danger signals of cells. We investigated whether NLRP3/NLRP1 inflammasomes are involved in the pathogenesis and progression of systemic lupus erythematosus (SLE). METHODS: Expressions of inflammasome components at the mRNA and protein levels in the peripheral blood...

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PMID: 24334646
DOI: 10.3899/jrheum.130310

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