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Article

Successful Treatment of Genetically Profiled Pediatric Extranodal NK/T-Cell Lymphoma Targeting Oncogenic STAT3 Mutation.

Pediatric blood & cancer - 1 Apr 2016

McEachron Troy A, Kirov Ivan, Wungwattana Minkkwan, Cortes Daisy, Zabokrtsky Keri B, Sassoon Aaron, Craig David, Carpten John D, Sender Leonard S

Abstract excerpt

Extranodal natural killer (NK)/T-cell lymphoma (ENKTCL) is a distinct type of non-Hodgkin lymphoma predominantly observed in Asian and Latin American adult males. A 12-year-old Hispanic female diagnosed with ENKTCL was enrolled in our genomic profiling research protocol. We identified specific somatic alterations consistent with diagnosis of ENKTCL as well as oncogenic mutations in MAP2K1 and STAT3. To our...

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Identifiers

PMID: 26727971
DOI: 10.1002/pbc.25854
PMCID: PMC7510171

Genes

STAT3

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