Batch effects in population genomic studies with low-coverage whole genome sequencing data: Causes, detection and mitigation.

Abstract excerpt

Over the past few decades, there has been an explosion in the amount of publicly available sequencing data. This opens new opportunities for combining data sets to achieve unprecedented sample sizes, spatial coverage or temporal replication in population genomic studies. However, a common concern is that nonbiological differences between data sets may generate patterns of variation in the data that can confound...

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