Article
Extremely low-coverage whole genome sequencing in South Asians captures population genomics information.
BMC genomics - 22 May 2017
Rustagi Navin, Zhou Anbo, Watkins W Scott, Gedvilaite Erika, Wang Shuoguo, Ramesh Naveen, Muzny Donna, Gibbs Richard A, Jorde Lynn B, Yu Fuli, Xing Jinchuan
Abstract excerpt
BACKGROUND: The cost of Whole Genome Sequencing (WGS) has decreased tremendously in recent years due to advances in next-generation sequencing technologies. Nevertheless, the cost of carrying out large-scale cohort studies using WGS is still daunting. Past simulation studies with coverage at ~2x have shown promise for using low coverage WGS in studies focused on variant discovery, association study replications,...
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