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Article

Batch effects in a multiyear sequencing study: False biological trends due to changes in read lengths.

Molecular ecology resources - 1 Jul 2018

Leigh D M, Lischer H E L, Grossen C, Keller L F

Abstract excerpt

High-throughput sequencing is a powerful tool, but suffers biases and errors that must be accounted for to prevent false biological conclusions. Such errors include batch effects; technical errors only present in subsets of data due to procedural changes within a study. If overlooked and multiple batches of data are combined, spurious biological signals can arise, particularly if batches of data are correlated...

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PMID: 29573184
DOI: 10.1111/1755-0998.12779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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