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Article

Arginase II polymorphisms modify the hypotensive responses to propofol by affecting nitric oxide bioavailability.

European journal of clinical pharmacology - 1 Jun 2021

Oliveira-Paula Gustavo H, Coeli-Lacchini Fernanda Borchers, Ferezin Letícia Perticarrara, Ferreira Graziele C, Pinheiro Lucas C, Paula-Garcia Waynice N, Garcia Luis V, Tanus-Santos Jose E, Lacchini Riccardo

Abstract excerpt

PURPOSE: Propofol anesthesia is usually accompanied by hypotensive responses, which are at least in part mediated by nitric oxide (NO). Arginase I (ARG1) and arginase II (ARG2) compete with NO synthases for their common substrate L-arginine, therefore influencing the NO formation. We examined here whether ARG1 and ARG2 genotypes and haplotypes affect the changes in blood pressure and NO bioavailability in...

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Identifiers

PMID: 33410970
DOI: 10.1007/s00228-020-03059-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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