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Article

Endothelial NO synthase polymorphisms and postural tachycardia syndrome.

Hypertension (Dallas, Tex. : 1979) - 1 Nov 2005

Garland Emily M, Winker Robert, Williams Scott M, Jiang Lan, Stanton Krista, Byrne Daniel W, Biaggioni Italo, Cascorbi Ingolf, Phillips John A, Harris Paul A, Rüdiger Hugo, Robertson David

Abstract excerpt

Postural tachycardia syndrome (POTS) is a heterogeneous disorder characterized by an excessive rise in heart rate and symptoms consistent with cerebral hypoperfusion in the upright position. NO produced by endothelial NO synthase is a significant factor in the regulation of blood flow. Genetic polymorphisms in the promoter region (T-786C) and exon 7 (E298D) of the NO synthase isoform 3 gene affect enzyme activity...

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PMID: 16203873
DOI: 10.1161/01.HYP.0000185462.08685.da

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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