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Article

Endothelial nitric oxide synthase polymorphisms affect the changes in blood pressure and nitric oxide bioavailability induced by propofol.

Nitric oxide : biology and chemistry - 1 May 2018

Oliveira-Paula Gustavo H, Lacchini Riccardo, Pinheiro Lucas C, Ferreira Graziele C, Luizon Marcelo R, Garcia Waynice N P, Garcia Luis V, Tanus-Santos Jose E

Abstract excerpt

Propofol anesthesia is usually accompanied by hypotension, which is at least in part related to enhanced endothelial nitric oxide synthase (NOS3)-derived NO bioavailability. We examined here whether NOS3 polymorphisms (rs2070744, 4b/4a VNTR, rs3918226 and rs1799983) and haplotypes affect the changes in blood pressure and NO bioavailability induced by propofol. Venous blood samples were collected from 168 patients...

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Source

Identifiers

PMID: 29496565
DOI: 10.1016/j.niox.2018.02.007

Genes

NOS3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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