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Label-Free Detection of DNA Base Mutation and Hybridized DNA by an Electrostatically Modified 3D Plasmonic Array.

ACS sensors - 23 Aug 2024

Xing Xiaolu, Zhao Yuhao, Zhao Haiyan, Zhang Ying, Chen Ziqiu, Liu Bowen, Ren Bin

Abstract excerpt

Surface-enhanced Raman scattering (SERS) represents a promising avenue for DNA detection as it offers intrinsic chemical insights with high sensitivity compared to conventional methods. However, label-free and quantitative detection of unmodified DNA by SERS remains a major challenge in DNA analysis. To overcome this challenge, we propose a positively charged plasmonic nanosurface for DNA capture and quantitative...

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PMID: 39039996
DOI: 10.1021/acssensors.4c01060

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