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Label-Free Detection of C-T Mutations by Surface-Enhanced Raman Spectroscopy Using Thiosulfate-Modified Nanoparticles.

Analytical chemistry - 2 Feb 2021

Zeng Jiayu, Dong Meiyu, Zhu Bixue, Gao Xin, Chen Dongmei, Li Yang

Abstract excerpt

Recent developments in molecular spectroscopy have widened the scope of surface-enhanced Raman spectroscopy (SERS) for detection of nucleic acids. In order to solve the interference of impurity signals in SERS analysis that hamper the reliable detection of DNA, Ag nanoparticles modified with thiosulfate ions were used to obtain SERS signals of DNA molecules in aqueous solutions, which showed good reproducibility....

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PMID: 33464044
DOI: 10.1021/acs.analchem.0c04052

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