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Article

COL5A1 gene variants previously associated with reduced soft tissue injury risk are associated with elite athlete status in rugby.

BMC genomics - 14 Nov 2017

Heffernan Shane M, Kilduff Liam P, Erskine Robert M, Day Stephen H, Stebbings Georgina K, Cook Christian J, Raleigh Stuart M, Bennett Mark A, Wang Guan, Collins Malcolm, Pitsiladis Yannis P, Williams Alun G

Abstract excerpt

BACKGROUND: Two common single nucleotide polymorphisms within the COL5A1 gene (SNPs; rs12722 C/T and rs3196378 C/A) have previously been associated with tendon and ligament pathologies. Given the high incidence of tendon and ligament injuries in elite rugby athletes, we hypothesised that both SNPs would be associated with career success. RESULTS: In 1105 participants (RugbyGene project), comprising 460 elite...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29143592
DOI: 10.1186/s12864-017-4187-3
PMCID: PMC5688435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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