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Article

Functional COL1A1 variants are associated with the risk of acute musculoskeletal soft tissue injuries.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Oct 2020

Gibbon Andrea, Raleigh Stuart M, Ribbans William J, Posthumus Michael, Collins Malcolm, September Alison V

Abstract excerpt

Studies have reported the association of the COL1A1 Sp1 binding site variant (rs1800012) with the risk of acute musculoskeletal soft tissue injuries. Interaction with the COL1A1 promoter variant (rs1107946) has also been proposed to modulate acute injury risk. Conversely, neither of these loci have been associated with chronic musculoskeletal soft tissue phenotypes. Therefore, the primary aim of this study...

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PMID: 32017203
DOI: 10.1002/jor.24621

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