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Article

A single evolutionarily divergent mutation determines the different FAD-binding affinities of human and rat NQO1 due to site-specific phosphorylation.

FEBS letters - 1 Jan 2022

Pacheco-Garcia Juan Luis, Loginov Dmitry, Rizzuti Bruno, Vankova Pavla, Neira Jose L, Kavan Daniel, Mesa-Torres Noel, Guzzi Rita, Man Petr, Pey Angel L

Abstract excerpt

The phosphomimetic mutation S82D in the cancer-associated, FAD-dependent human NADP(H):quinone oxidoreductase 1 (hNQO1) causes a decrease in flavin-adenine dinucleotide-binding affinity and intracellular stability. We test in this work whether the evolutionarily recent neutral mutation R80H in the vicinity of S82 may alter the strong functional effects of S82 phosphorylation through electrostatic interactions. We...

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PMID: 34817874
DOI: 10.1002/1873-3468.14238

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