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Article

Metabolic Enzyme Alterations and Astrocyte Dysfunction in a Murine Model of Alexander Disease With Severe Reactive Gliosis.

Molecular & cellular proteomics : MCP - 1 Jan 2022

Heaven Michael R, Herren Anthony W, Flint Daniel L, Pacheco Natasha L, Li Jiangtao, Tang Alice, Khan Fatima, Goldman James E, Phinney Brett S, Olsen Michelle L

Abstract excerpt

Alexander disease (AxD) is a rare and fatal neurodegenerative disorder caused by mutations in the gene encoding glial fibrillary acidic protein (GFAP). In this report, a mouse model of AxD (GFAPTg;Gfap+/R236H) was analyzed that contains a heterozygous R236H point mutation in murine Gfap as well as a transgene with a GFAP promoter to overexpress human GFAP. Using label-free quantitative proteomic comparisons of...

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Identifiers

PMID: 34808356
DOI: 10.1016/j.mcpro.2021.100180
PMCID: PMC8717607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Metabolic Enzyme Alterations and Astrocyte Dysfunction in a Murine Model of Alexander Disease With Severe Reactive Gliosis.PMID 34808356Read ↗

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A multi-omics approach reveals impaired lipid metabolism and oxidative stress in a zebrafish model of Alexander disease.Semantic proximity Read ↗

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