Article
Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways.
Human molecular genetics - 1 Jun 2008
Tang Guomei, Yue Zhenyu, Talloczy Zsolt, Hagemann Tracy, Cho Woosung, Messing Albee, Sulzer David L, Goldman James E
Abstract excerpt
Glial fibrillary acidic protein (GFAP) is the principle intermediate filament (IF) protein in astrocytes. Mutations in the GFAP gene lead to Alexander disease (AxD), a rare, fatal neurological disorder characterized by the presence of abnormal astrocytes that contain GFAP protein aggregates, termed Rosenthal fibers (RFs), and the loss of myelin. All GFAP mutations cause the same histopathological defect, i.e....
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