Cellular Models for Studying Alexander Disease: Functional Analysis of Primary Rat Astrocytes.

Abstract excerpt

Astrocytes play a vital role in maintaining central nervous system homeostasis, supporting neuronal function, and responding to injury or disease. Dysfunction in astrocyte activity is increasingly recognized as a key contributor to neurodegenerative disorders, including Alexander disease (AxD), a rare and fatal condition caused by mutations in glial fibrillary acidic protein (GFAP). These mutations result in GFAP...

Topics

• Animals
• Astrocytes
• Alexander Disease
• Rats
• Glial Fibrillary Acidic Protein
• Disease Models, Animal
• Mutation