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Article

Genetic profiling of MYC and BCL2 in diffuse large B-cell lymphoma determines cell-of-origin-specific clinical impact.

Blood - 18 May 2017

Ennishi Daisuke, Mottok Anja, Ben-Neriah Susana, Shulha Hennady P, Farinha Pedro, Chan Fong Chun, Meissner Barbara, Boyle Merrill, Hother Christoffer, Kridel Robert, Lai Daniel, Saberi Saeed, Bashashati Ali, Shah Sohrab P, Morin Ryan D, Marra Marco A, Savage Kerry J, Sehn Laurie H, Steidl Christian, Connors Joseph M, Gascoyne Randy D, Scott David W

Abstract excerpt

The clinical significance of MYC and BCL2 genetic alterations in diffuse large B-cell lymphoma (DLBCL), apart from translocations, has not been comprehensively investigated using high-resolution genetic assays. In this study, we profiled MYC and BCL2 genetic alterations using next-generation sequencing and high-resolution SNP array in 347 de novo DLBCL cases treated with R-CHOP (rituximab, cyclophosphamide,...

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Share to Disease Progression
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kaplan-Meier Estimate

Share to Lymphoma, Large B-Cell, Diffuse

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Share to Proto-Oncogene Proteins c-bcl-2

Share to Proto-Oncogene Proteins c-myc

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Source

Identifiers

PMID: 28351934
DOI: 10.1182/blood-2016-11-747022

Genes

BCL2
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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