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Analysis of the Zika and Japanese Encephalitis Virus NS5 Interactomes

14 Jun 2019

Abstract excerpt

Mosquito-borne flaviviruses, including dengue virus (DENV), Japanese encephalitis virus (JEV), and Zika virus (ZIKV), are major human pathogens. Among the flaviviral proteins, the nonstructural protein 5 (NS5) is the largest, most conserved, and major enzymatic component of the viral replication complex. Disruption of the common key NS5-host protein-protein interactions critical for viral replication could aid in...

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PMID: 31199156
DOI: 10.1021/acs.jproteome.9b00318

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