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In Vitro and In Vivo Stability of P884T, a Mutation that Relocalizes Dengue Virus 2 Non-structural Protein 5.

ACS infectious diseases - 10 Dec 2021

Cheng Colin X, Alvin Tan Min Jie, Chan Kitti W K, Watanabe Satoru, Wang Sai, Choy Milly M, Manuel Menchie, Victorio Carla B L, Ong Joanne, Reolo Marie, Chacko Ann-Marie, Vasudevan Subhash G

Abstract excerpt

Dengue virus (DENV) non-structural protein 5 (NS5) is critical for viral RNA synthesis within endoplasmic reticulum (ER)-derived replication complexes in the cytoplasm; however a proportion of NS5 is known to be localized to the nucleus of infected cells. The importance of nuclear DENV NS5 on viral replication and pathogenesis is still unclear. We recently discovered a nuclear localization signal (NLS) residing...

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PMID: 34735113
DOI: 10.1021/acsinfecdis.1c00441

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